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1994-08-09
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Document 0089
DOCN M9480089
TI Oral candidiasis and immune status of HIV-infected patients.
DT 9410
AU Nielsen H; Bentsen KD; Hojtved L; Willemoes EH; Scheutz F; Schiodt M;
Stoltze K; Pindborg JJ; Department of Oral Pathology, School of
Dentistry, University of; Copenhagen, Denmark.
SO J Oral Pathol Med. 1994 Mar;23(3):140-3. Unique Identifier : AIDSLINE
MED/94293201
AB A total of 84 HIV-infected homosexual men having either normal oral
mucosa (NOM), erythematous candidiasis (EC) or pseudomembranous
candidiasis (PsC) were included in the study. The patients were
evaluated by median number of peripheral CD4+ cells, CD8+ cells and by
lymphocyte function assessed by poke-weed mitogen test. There was a
significant difference between CD4+ counts among patients with the two
subtypes of candidiasis (95% CI of median difference: 10-240/mm3; P =
0.03), but not for pokeweed mitogen response. Survival analysis showed
that after 2 y there was no significant difference in development of
AIDS between patients with EC and PsC (P = 0.29). If patients with both
types of oral candidiasis were pooled and compared with patients with
NOM, a significant difference in development of AIDS was found (P =
0.04). It is concluded that HIV-infected patients with oral candidiasis
of any subtype (EC or PsC) are significantly more immune suppressed and
show a faster development of AIDS than HIV-infected patients with NOM.
However, in this cohort, EC and PsC are of equal importance as
predictors for immune suppression and AIDS development.
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY Adult Candidiasis,
Oral/*IMMUNOLOGY/PATHOLOGY Cohort Studies Follow-Up Studies Human
HIV Infections/*IMMUNOLOGY HIV Seropositivity/*IMMUNOLOGY Leukocyte
Count Longitudinal Studies Lymphocyte Transformation Male Middle Age
Mouth Mucosa/*IMMUNOLOGY T-Lymphocytes, Cytotoxic/IMMUNOLOGY/PATHOLOGY
T4 Lymphocytes/IMMUNOLOGY/PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).